Cancer Biology & Therapy

Journal Title：Cancer Biology & Therapy

Cancer, the second leading cause of death, is a heterogenous group of over 100 diseases. Cancer is characterized by disordered and deregulated cellular and stromal proliferation accompanied by reduced cell death with the ability to survive under stresses of nutrient and growth factor deprivation, hypoxia, and loss of cell-to-cell contacts. At the molecular level, cancer is a genetic disease that develops due to the accumulation of mutations over time in somatic cells. The phenotype includes genomic instability and chromosomal aneuploidy that allows for acceleration of genetic change. Malignant transformation and tumor progression of any cell requires immortalization, loss of checkpoint control, deregulation of growth, and survival. A tremendous amount has been learned about the numerous cellular and molecular genetic changes and the host-tumor interactions that accompany tumor development and progression. It is the goal of the field of Molecular Oncology to use this knowledge to understand cancer pathogenesis and drug action, as well as to develop more effective diagnostic and therapeutic strategies for cancer. This includes preventative strategies as well as approaches to treat metastases. With the availability of the human genome sequence and genomic and proteomic approaches, a wealth of tools and resources are generating even more information. The challenge will be to make biological sense out of the information, to develop appropriate models and hypotheses and to translate information for the clinicians and the benefit of their patients. Cancer Biology & Therapy aims to publish original research on the molecular basis of cancer, including articles with translational relevance to diagnosis or therapy. We will include timely reviews covering the broad scope of the journal. The journal will also publish op-ed pieces and meeting reports of interest. The goal is to foster communication and rapid exchange of information through timely publication of important results using traditional as well as electronic formats. The journal and the outstanding Editorial Board will strive to maintain the highest standards for excellence in all activities to generate a valuable resource.

癌癥是第二大死亡原因，是一類由 100 多種疾病組成的異質性疾病。癌癥的特征是細胞和基質增殖紊亂和失調，伴隨細胞死亡減少，在營養和生長因子缺乏、缺氧和細胞間接觸喪失的壓力下仍能存活。在分子水平上，癌癥是一種遺傳性疾病，是由于體細胞中突變隨時間積累而發展起來的。其表型包括基因組不穩定性和染色體非整倍性，這加速了基因變化。任何細胞的惡性轉化和腫瘤進展都需要永生化、檢查點控制喪失、生長失調和存活。人們對伴隨腫瘤發展和進展的眾多細胞和分子遺傳變化以及宿主-腫瘤相互作用有了大量的了解。分子腫瘤學領域的目標是利用這些知識來了解癌癥的發病機制和藥物作用，以及開發更有效的癌癥診斷和治療策略。這包括預防策略以及治療轉移的方法。隨著人類基因組序列以及基因組和蛋白質組學方法的出現，大量的工具和資源正在產生更多的信息。挑戰在于從信息中得出生物學意義，開發適當的模型和假設，并為臨床醫生和患者提供信息?！栋┌Y生物學與治療》旨在發表關于癌癥分子基礎的原創研究，包括與診斷或治療具有轉化相關性的文章。我們將及時發表涵蓋期刊廣泛范圍的評論。該期刊還將發表感興趣的評論文章和會議報告。目標是通過使用傳統和電子格式及時發表重要結果來促進溝通和快速信息交換。該期刊和優秀的編輯委員會將努力在所有活動中保持最高的卓越標準，以產生寶貴的資源。

Cancer Biology & Therapy創刊于2002年，由Landes Bioscience出版商出版，收稿方向涵蓋醫學 - 腫瘤學全領域，此期刊水平偏中等偏靠后，在所屬細分領域中專業影響力一般，過審相對較易，如果您文章質量佳，選擇此期刊，發表機率較高。平均審稿速度 約2.3月 ，影響因子指數4.4，該期刊近期沒有被列入國際期刊預警名單，廣大學者值得一試。